Endocrine Abstracts

GAPO syndrome (OMIM 230740) is a rare, multiple congenital anomalies syndrome characterized by Growth retardation, Alopecia, Pseudoanodontia and Ocular manifestations. Syndrome caused by anthrax toxin receptor 1 (ANTXR1) gene (NM_032208.2) mutation leading to deficiency of an enzyme involved in the metabolism and breakdown of extracellular matrix (ECM). Disease show parental consanguinity, autosomal recessive inheritance and since first description in 1947 a total of 38 patien...

Aim: Ghrelin plays an important role in stimulation of food intake and long-term regulation of body weight. In present study we aimed to investigate the effect of exenatide treatment on serum ghrelin levels in patients with type 2 diabetes.Methods: Fourteen women patients with type 2 diabetes treated with metformin and exenatide were enrolled in the study. A mixed meal test was applied to the patients while they were using their daily medications. Serum ...

Aim: To assess the contribution of macroprolactin (macroPRL) to high serum prolactin (PRL) levels and association of prolactin and macroprolactin levels with thyroid status and thyroid autoimmunity during pregnancy.Methods: Pregnant women (n=138) who had undergone a thyroid-stimulating hormone (TSH) screening during the first trimester of pregnancy enrolled in the study. Serum prolactin, macroprolactin, TSH, FT4, FT3, and thyroid autoantibodies ...

Aim: In our study, we aimed to evaluate the relationship between oxidative stress markers such as total antioxidant capacity (TAC), advanced oxidant protein products (AOPP) and thiol-disulfide homeostasis parameters and diabetic peripheral neuropathy (PNP), an important microvascular complication of diabetes mellitus (DM).Material and methods: 80 (male/female=34/46) patients with type 2 DM and 19 healthy controls were included in the stu...

Introduction: In obesity, MPV is found higher compared to healthy controls. It was found that the level of NLR was predictive of the development of type 2 diabetes with high sensitivity and specificity in morbid obese patients. PLR is a new biological indicator that can assess the presence and severity of inflammation. However, in obese patients PLR was not found to associate with degree of of obesity or ratio of weight loss. Regarding the platelet count (PC) in obesity, confl...

Aim: We aimed to investigate the possible relationship between HDL cholesterol subclasses and carotid intima media thickness (CIMT) in patients with type 1 diabetes mellitus (DM).Material and methods: Sixty-two (female/male: 33/29, mean age: 33.3±8.5 years) patients with type 1 DM at least 5 years and 20 (female/male: 10/10, mean age: 30.4±5.6 years) healthy controls were included in the study. After physical examination and anthropometric meas...